The history, policies and practice of drug control in Asia have been historically multifaceted, particularly concerning substances like opium, cannabis, and various indigenous psychoactive plants. The opium trade, notably in the 19th and early 20th centuries, significantly impacted Asian societies, triggering conflicts, influencing international relations, and altering the socio-economic fabric. Yet, the history of drug control across different parts of Asia reflects a complex interplay of factors and a stark regional diversity. This special issue serves as a platform for interdisciplinary studies that link Asian drug trafficking with collaborative legal responses across the region. The primary objective is to compile an overview of the history, current practices, and policies addressing drug production, trafficking, and usage in a continent that houses 60% of the global population. This is done by sampling articles that encompass the large geographical scope of Asia, from Northeast Asia to the Middle East. The special issue focuses on three key dimensions of drug control that affect Asian countries: Historical landmarks, including milestones of drug control policy developments at the national level, which shaped the international regime over the last two centuries; public health and history of local responses with the analysis of the burden of infectious diseases, and the state of access to controlled essential medicines; and, criminal justice and historical landmarks of its development through legal responses and punishments.