This paper investigates a communist plan in the 1920s to establish a Middle Eastern center in the port city of Thessaloniki. To explain this counterintuitive choice, the paper situates Thessaloniki within two radical spaces. First, it shows the importance of post-Ottoman radical networks in making Thessaloniki a critical point of liaison in the 1920s. Second, it discusses the radical connections across the Mediterranean and the agency of revolutionary sailors in establishing these linkages.